At least two people were killed when a small plane crashed on Interstate 75 near Naples, Fla., on Friday afternoon, according to the Federal Aviation Administration.

The plane, a Bombardier Challenger 600 series jet, was carrying five people when it crashed on the highway around 3:15 p.m., the F.A.A. said in a statement. It was not immediately clear if the plane crashed into any cars or whether anyone on the ground was injured.

Photos and video footage from the scene showed the aircraft’s fuselage in flames and a large plume of smoke billowing above the crash site.

A six-mile stretch of the interstate will be closed for at least 24 hours, according to the Collier County Sheriff’s Office.

Local officials were encouraging people to avoid the area while the F.A.A. and the National Transportation Safety Board investigated, officials said. Florida Highway Patrol troopers were also at the scene.

The aircraft, which officials said had the registration number N823KD, was traveling from Ohio to Naples on Friday afternoon, according to FlightAware. Its next destination was Fort Lauderdale, according to FlightAware.

This is a developing story.